You don’t have Lyme because your results says positive IGM and negative IGG
As in one of my previous posts, Dr. Gollum didn’t believe my results from IgeneX because I had positive IGM and negative IGG. And he was skeptical because I “claimed” that my symptoms have been for over a year. In short:
IGM = current infection
IGG = past infection
So, attending my weekly awesome Lyme webinars from a really awesome doc in Seattle, Washington named Dr. Marty Ross (www.treatlyme.net), I asked this question and here is the response I got. I typed it up and I think I will shove it into Dr. Gollum’s face.
Q: I have been infected for more than 6 mths – 1 year. My family doc does not believe that I have lyme even though my igenex has 2 positive IGM Bands. He said he would believe it if the IGG was positive since the infection was more than a year ago. Is this right? Why would my IGM be postive and IGG be negative if this infection was more than 6 months ago?
A: There are 2 families of antibodies when trying to determine if somebody’s immune system is reacting to any germ. One of those families is IGM and the other is IGG. Always when you get infected, you develop IGM antibodies, and then for most infections EXCEPT Lyme disease, in most cases, IGM’s will go away within 6 weeks – 3 months and be replaced by IGG’s. When you develop IGG antibodies in an infection including Lyme, they will remain positive even after the illness is gone. What we say when we look at the IGG antibody is that it serves as the “memory” of the immune system. When it comes back positive, we cannot tell if the germ is in you or out of you, the best we can say about a positive IGG is that you had the infection.
Now, IGM Antibodies in Lyme can remain positive indefinitely. If they do, it means you have a living germ in you. Any germ covering is made up of a layer of fat (phospholipids), into which proteins get stuck. So in short, a germ covering is proteins stuck in fat. In all infections EXCEPT Lyme and a handful of other infections, those proteins that get stuck are static. They do not move around. Therefore what the germ looks like to the immune system never changes. In the case of Lyme and a few other infections, those proteins do get moved around. There are 14 kinds of proteins in the Lyme germ. If those move, what the germ looks like is going to change and the immune system gets tricked into thinking it’s seeing a new infection and keeps making positive IGM antibodies.
One of the reasons why your doc may not believe you about your positive western blot test is because he is going to be doing what we were taught. IGM’s are supposed to go away and that by 3 months or so they should be gone and you should then be having IGG Antibodies. And what he is thinking in his mind as most doctors do is that you are having a false positive test. They are ignoring the science that says you can have this phenomenon known in Lyme and it’s called Epitope Switching or Antigenic Variation. There is good science that supports this in Lyme.